mTOR-IN-1 - CAS# 1207358-59-5 Catalog No.:M9817-2 5 hours post-dose

5 hours post-dose

127(2):287-289

InChiKey: KGCJWSUJYBJBBW-BTJKTKAUSA-N

4]diazacyclopentadecin-2-yl 4-fluoroisoindoline-2-carboxylate

IWR-1 inhibits cell proliferation and EMT even in the presence of TNF-α-induced cancer cell stimulation

mTOR-IN-1 - CAS# 1207358-59-5 Catalog No.:M9817-2 5 hours post-dosemTOR IN 1 is a remarkably selective mTOR inhibitor with a Ki of 1. 5 nM. mTOR IN 1 suppresses mTORC1 and mTORC2 in cellular and in vivo pharmacokinetic (PK) pharmacodynamic (PD) experiments. In Vitro: mTOR IN 1 (Compound 12i) inhibits mTOR with a Ki of 1. 5 nM, 500 fold selectivity over closely related PI3 kinases. mTOR IN 1 inhibits NCI PC3 and MCF7neo Her2 cells proliferation with IC50s of 150 nM and 57 nM, respectively[2]. In Vivo: mTOR IN 1