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Formula: C35H46FN5O9S
96(1):38-46
Salirasib reduces phosphorylation of S6K but not of ERK in the TSC2-null ELT3 cells
effectively substituting for the structural role of the catalytic lysine and resulting in the ordering of helix C and stabilization of an active conformation
Solubility: DMSO up to 15 mM
TBA-354 Catalog No.:M8471-2 Formula: C35H46FN5O9STBA 354, also known as SN31354, is a potent anti tuberculosis drug candidate. TBA 354 is narrow spectrum and bactericidal in vitro against replicating and nonreplicating Mycobacterium tuberculosis, with potency similar to that of delamanid and greater than that of PA 824. TBA 354 maintains activity against Mycobacterium tuberculosis H37Rv isogenic monoresistant strains and clinical drug sensitive and drug resistant isolates. TBA 354 is a promising