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NCB-0846 binds to TNIK in an inactive conformation
and PC-9exon 19Del with IC50 of 64
OSU-03012 promotes cell killing to a greater extent in glioma cells than in nontransformed astrocytes
Gowler PRW
It is a competitive inhibitor of quinone and targets the Q-site of NDH-2
Omadacycline mesylate histerone NCB-0846 binds to TNIK inOmadacycline, also known as PTK 0796 and Amadacyclin, is a novel first in class aminomethylcycline with potent activity against important skin and pneumonia pathogens, including community acquired methicillin resistant Staphylococcus aureus (MRSA), hemolytic streptococci, penicillin resistant Streptococcus pneumoniae, Haemophilus influenzae, and Legionella. Omadacycline is active against strains expressing the two main forms of tetracycline resistance
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