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16(6):922-32
29)/t13-/m1/s1
distinct from CPPHA
Treatment of two mouse models of obesity/diabetes with WWL113 ameliorates multiple features of metabolic syndrome
The exocyclic amino group in MGCD0103 is necessary for enzyme inhibitory activity because HDAC-inhibitory activity against HDAC1 and HDAC2 is completely abolished with the desamino analogue
ABT-100 - CAS# 450839-40-4 size:2mg solid 16(6):922-32ABT 100, CAS No. 450839 40 4, is an orally bioavailable farnesyltransferase inhibitor. ABT 100 inhibited proliferation of cells in vitro carrying oncogenic H Ras (EJ 1 bladder; IC(50) 2. 2 nmol L), Ki Ras (DLD 1 colon, MDA MB 231 breast, HCT 116 colon, and MiaPaCa 2 pancreatic; IC(50) range, 3. 8 9. 2 nmol L), and wild type Ras (PC 3 and DU 145; IC(50), 70 and 818 nmol L, respectively) as well as clonogenic potential. ABT 100 shows 70% to 80% oral
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