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It inhibits HDAC1 and HDAC3 with IC50 of 0
PubMed PMID: 17962474
also known as L-Gly-7-Amino-4-Methylcoumarin
is a potent inhibitor of PERK with an IC50 of 5 nM
Smiles: OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O
EBE-A22 Catalog No.:M10416-10 It inhibits HDAC1 and HDAC3EBE A22 is a derivative of PD 153035. EBE A22, has no effect on EGF R TK but maintains a high cytotoxic profile. EBE A22 binds to DNA and behave as typical intercalating agents. EBE A22 unwinds supercoiled plasmid, stabilizes duplex DNA against heat denaturation, and produces negative CD and ELD signals, as expected for an intercalating agent. EBE A22, but not PD153035, interacts preferentially with GC rich sequences and discriminates against
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