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is a potent and selective inhibitor of the bromodomain of the BRPFs
including all known mGlu receptors
CAS Number: 1002789-86-7
InChiKey: FBKMWOJEPMPVTQ-UHFFFAOYSA-N
Chemical Name: (S)-4-(3-hexylureido)-N-(4-(2-((2-hydroxy-3-(4-hydroxyphenoxy)propyl)amino)ethyl)phenyl)benzenesulfonamide
PFI-4 - BRPF1 Bromodomain Inhibitor. CAS# 900305-37-5 60165 is a potent and selectivePFI 4, CAS No. 900305 37 5, is a potent, selective and cell permeable BRPF1 bromodomain inhibitor. It binds to BRPF1B with a Kd of 13 nM (ITC). It has general >100 fold selectivity against other bromodomains including BRPF2, BRPF3 and BRD4. It reduces recovery time in triple BRD cell construct in FRAP and is potent in cells with IC50 250 nM, while showing no effect on BRPF1A. Product information CAS Number: 900305 37 5 Molecular Weight: 380. 44
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