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Schaefer M
PubMed PMID: 15860572
The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901
enzymes and transporters
93(11):1951-2
KPT-330 - CAS# 1393477-72-9 009 Schaefer MKPT 330, CAS No. 1393477 72 9, is an orally bioavailable, potent and selective XPO1 CRM1 Inhibitor. KPT 330 is effective in acquired resistance to ibrutinib and synergizes with ibrutinib in chronic lymphocytic leukemia. KPT 330 potentiates the antitumor activity of gemcitabine in human pancreatic cancer through inhibition of tumor growth, depletion of the antiapoptotic proteins, and induction of apoptosis. KPT 330 has strong activity against primary
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