Effects that interact with your library in any other way won't make you lose the game even if they ask you to interact with an empty library
Most obviously, Nyxborn Behemoth is a sticky 10/10 with trample that you can sacrifice enchantments for to make it indestructible
Sure, your opponent might have ten beasts in their green deck, but Callous Oppressor would still be able to steal their four goblins, three elves, and two other creatures that weren't beasts
Giving either legend protection from blue and black is a fantastic mode, and while youd like to be immune from Path or Swords, this covers most of your other bases
In a deck with lots of other mill effects, you can double the amount of cards your opponent mills, giving you more options for spells to cast