AZD6244 (Selumetinib) - MEK Inhibitor. CAS# 606143-52-6 0192 has been reported recently to

has been reported recently to act as a selective breast cancer stem cell inhibitor

Suppression of the clinical and cytokine response to endotoxin by RWJ-67657

van Kampen RJ

2016 May 19

2017 Feb 14

AZD6244 (Selumetinib) - MEK Inhibitor. CAS# 606143-52-6 0192 has been reported recently toAZD6244, CAS No. 606143 52 6, (Selumetinib, ARRY 142886) is an orally active, highly potent and selective non ATP competitive MEK inhibitor, inhibiting MEK1 with an IC50 of 14 nM. In vitro cell viability inhibition screening of a tumor cell line panel found that cell lines harboring BRAF or RAS mutations were more likely to be sensitive to AZD6244. Treatment of primary HCC cells with AZD6244 led to growth inhibition, caspase 3 and caspase 7