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• Side-seamed construction
3 cm) in diameter
start by making and testing a group of five compounds (including the unsubstituted phenyl compound)
• 15 oz mug dimensions: 4
• 10 mil (0
Topliss Tree for Aromatic Substitutions • Side-seamed constructionThe Topliss tree is a simple stepwise process for phenyl group optimization. By making a few compounds sequentially following the Topliss tree, you can quickly identify a more potent tool compound for use in protein co crystallization or a functional assay. The preliminary SAR this generates also helps prioritize your many hits and identify which compounds have no rational SAR and are likely just assay interference compounds. This poster has a partly