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ZXH-3-26 is a selective PROTAC BRD4 degrader
4]diazepin-2-one
PLX-4720 treatment at 30 mg/kg/day significant inhibits the tumor growth of 8505c xenografts by >90%
2003 Jun 24
AMI-1 was used at 10-30 µM final concentration in vitro and in cellular assays
PHA-680632 182 ZXH-3-26 is a selective PROTACPHA 680632 is a is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. PHA 680632 is also the first representative of a new class of Aurora inhibitors with a high potential for further development as an anticancer therapeutic. PHA 680632 is active on a wide range of cancer cell lines and shows significant tumor growth inhibition in different animal tumor models at well tolerated doses. Product